A high-yield, one-pot, scalable reaction facilitates the production of biologically relevant amide compounds using less reactive nitrogen-containing heterocyclic compounds and carboxylic acid without ...

Takeaway 3: The Alcohol-to-Amide Shortcut The team extended their logic to create a "one-pot" enzymatic cascade that starts from broadly available aliphatic alcohols. This chemoenzymatic strategy is ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

Amides represent one of the most abundant and versatile functional groups in organic chemistry, featuring prominently in pharmaceuticals, agrochemicals and advanced materials. Their inherent stability ...

(4) Carboxylic acids and amines themselves do not react to form amides. Instead, a process activates the carboxylic acid, making it susceptible to amide formation. I don't get paid enough to broach ...

A team at UNC-Chapel Hill has developed a new process for synthesizing amides in a 100% atom-economical, sustainable fashion using Earth-abundant, environmentally friendly cobalt. UNC-Chapel Hill ...

Extending or trimming the length of a drug molecule’s carbon backbone by just a couple of atoms can significantly alter its activity, even if nothing else in the structure changes. So reactions that ...

Chemists from HSE University and the Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences (INEOS RAS) have developed a new method for synthesising amides, essential ...

A study published in Small examined how modifying the surface charge of covalent organic frameworks (COFs) affects platinum (Pt) photodeposition and photocatalytic hydrogen evolution. The researchers ...