One of the main goals of proteomics is to unravel the many modifications important for biological activity. Post-translational modifications (PTMs) extend the range of protein function by attaching it ...

The focus of vertebrate studies has mainly been on canonical phosphorylation, but research indicates that phosphorylation of other non-canonical amino acids also regulates integral aspects of cell ...

The amino acid side chains of proteins undergo various post-translational modifications (PTMs) which significantly impact protein function and mediate complex cellular events. Measuring the dynamics, ...

image: An engineered protein nanopore directed a water flux strong enough to capture, unfold and translocate proteins exceeding 1200 amino acids in length. Modulation of electrical current during ...

A team of scientists led by the University of Oxford have achieved a significant breakthrough in detecting modifications on protein structures. The method, published in Nature Nanotechnology, employs ...

Tsukuba, Japan—Proteins are subject to post-translational chemical modifications that result in functional diversity. Methylation is one such modification that is generally believed to occur on lysine ...

A new statistical model demonstrates the ability to correctly predict the folding mechanisms for both small and large proteins. The function of a protein is determined by its structure. From the rigid ...

One of the first things that students learn when they enter a biology class is the central dogma: DNA → messenger RNA → proteins. Only about 3% of the human genome directly codes for proteins, which ...