Preclinical models of epilepsy and seizure disorders encompass a spectrum of in vitro, ex vivo and in vivo systems designed to recapitulate distinct aspects of seizure initiation, propagation and ...

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

For families of children with severe epilepsy, controlling seizures is often just the beginning of their challenges. Even in cases where powerful medications can reduce seizures, many children ...

In a world first, a research team at the University of Zurich has successfully treated mice carrying an inherited form of epilepsy. The scientists used gene editing to fix faulty DNA directly in the ...

Every year, more than 100 million animals are used globally in biomedical research, yet over 90% of drugs that appear effective in animal trials fail during human clinical testing. 1 This staggering ...

It is known that the antiepileptic drug valproate increases the risk of developmental disorders in unborn children. A study ...