Nature

Model Selection and Dose-Response Relationships in Clinical Trials

The development of robust clinical trial methodologies increasingly relies on advanced statistical frameworks for model selection and the characterisation of dose–response relationships. With modern ...
National Academies of Sciences%2c Engineering%2c and Medicine

Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene

EPA asked for an evaluation of whether conclusions it has drawn in the draft IRIS assessment are consistent with its cancer guidelines (EPA 2005a), specifically with regard to its characterization ...
BMJ

Optimal dose and type of physical activity to improve functional capacity and minimise adverse events in acutely hospitalised older adults: a systematic review with dose ...

Objective To identify the optimal dose and type of physical activity to improve functional capacity and reduce adverse events in acutely hospitalised older adults. Design Systematic review and ...
BMJ

Long-term leisure-time physical activity and risk of all-cause and cardiovascular mortality: dose–response associations in a prospective cohort study of 210 327 Taiwanese adults

2 CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain Objectives We aimed to investigate the dose–response associations of long-term leisure-time physical activity (LTPA) obtained from ...