Cryogenic optical microscopy uncovers multiple conformations of PIEZO1 in cell membranes, offering atomic-scale insights into how cells sense force. The team focused on PIEZO1, a mechanosensitive ion ...

Junior-Professor Daqing Wang from the University of Bonn has received a Proof of Concept Grant from the European Research ...

Fluorescent image of PIEZO1 in native cell membrane (left) and an artistic representation of its conformational states resolved with Ångström precision (right). Our remarkable ability to perform ...

Fluorescence microscopy reveals cellular morphology and dynamics in remarkable detail, but achieving clear visualization at fast acquisition rates remains a challenge. A fundamental trade-off between ...

Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a ...

Osaka, Japan – Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, ...

Microscopes have long served as windows into the hidden world of cells, revealing their shape, activity, and chemistry. Yet watching life at this scale has always involved trade-offs. To capture the ...

A) high-voltage cryo-electron microscope installed at the Osaka University. B) 250 nm diameter tokyovirus particle reconstructed at 7.7 Å resolution. The 2-fold, 3-fold, and 5-fold symmetry axes of ...

Researchers use cryo-EM and optical tweezers to investigate how an antiviral interacts with the herpes simplex virus.