The ubiquitin–proteasome system orchestrates pivotal regulatory pathways in cancer cells by marking key proteins for destruction or stabilisation. Central to this machinery are E3 ubiquitin ligases, ...

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Center have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

Definition: A restriction enzyme is a DNA-cutting protein, found mainly in bacteria and archaea, that recognizes a specific short DNA sequence and cleaves the double helix at or near that site. By ...

DNA-protein crosslinks (DPCs) are bulky lesions formed when proteins become covalently attached to DNA, arising from endogenous metabolism, environmental agents or the action of specialised enzymes ...