A large meta-analysis reveals that most antipsychotics achieve near-maximal efficacy at the lower end of recommended dose ranges, typically around 3-5 mg/d of risperidone equivalents.

Objective To estimate the dose–response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population. Design Systematic ...

Under Project Optimus, the FDA now expects oncology sponsors to evaluate multiple clinically relevant doses using the totality of the evidence and to identify the dosage that “m ...