Your skin cells are clearly different from your brain cells even though they both develop in the same person and carry the same genes. They are different because each cell type expresses a particular ...

As cells mature and differentiate (right), they use a much more elaborate and cell-type specific ‘switchboard’ to control their gene expression, especially when compared to earlier, immature stages ...

(A) Overview of the cohort, including all de novo acute megakaryoblastic leukemia subtypes (n = 75), compared with mononuclear cells derived from the bone marrow (BM) of non-cancer donors under 18 ...

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES neuronal ...

A team of researchers unveils a novel, key aspect of enhancer-mediated regulation of gene expression and proposes a mechanism that explains the tight connection between gene enhancers and promoters.