G protein coupled receptors (GPCRs) are essential drug targets for therapeutic intervention due to their integral roles in a plethora of fundamental signal transduction pathways. Indeed, GPCRs have a ...

Figure 1: Comparison of residue contacts in inactive- and active-state structures of class A GPCRs. The combinatorial possibilities of structural comparisons of multiple receptors make it difficult to ...

After Jonathan Violin completed his Ph.D. at the University of California, San Diego, he wanted to continue his research with a high-profile scientist working on G-protein-coupled receptors (GPCRs).

NEW YORK, NY (April 27, 2022)--Roughly a third of all drugs approved by the U.S. Food and Drug Administration target a large family of biomolecules, known as G protein-coupled receptors (GPCRs), whose ...

With approximately 30 to 40 percent of all marketed prescription pharmaceuticals acting on G protein-coupled receptors (GPCRs), these receptors remain attractive investigational drug targets, even ...

Then, on Aug. 4, 2000, structural biologists published the first X-ray structure of a GPCR. That day, an elated Topiol charged into a meeting, the journal article held aloft. “It was all very exciting ...

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are ...

PENZBERG, Germany--(BUSINESS WIRE)-- G-coupled protein receptors (GPCRs), also known as 7-transmembrane proteins, constitute the single largest class of therapeutic targets for clinical and ...

Researchers have developed a new tool to better understand how chemicals like dopamine and epinephrine interact with neurons. University of Michigan researchers have developed a new tool to better ...