Trans-splicing is a unique process in gene expression where a short sequence, known as a spliced leader (SL), is added to the 5' end of mRNA molecules. This mechanism is particularly significant in ...

Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...

Although heart cells and skin cells contain identical instructions for creating proteins encoded in their DNA, they're able to fill such disparate niches because molecular machinery can cut out and ...

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

Scientists at the Hospital for Sick Children (SickKids) and the University of Las Vegas Nevada (UNLV) have uncovered a genetic link between autism spectrum disorder (ASD) and a rare genetic condition ...

Tokyo Medical and Dental University (TMDU) researchers harness long-read RNA sequencing to decode genetic intricacies and disease links. Alternative splicing, a process where a single gene can give ...

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...

Approximately 2% to 6% of familiar dilated cardiomyopathy (DCM) cases are caused by inherited mutations in the RBM20 gene, which encodes the RNA binding motif 20 (RBM20), a splicing factor that ...