Engineered enzymes enable greener one-pot amide synthesis for drug manufacturing

A single type of chemical structure that shows up again and again in modern medicine is the amide bond that links a carbonyl group (C=O) to a nitrogen atom. They're so ubiquitous that 117 of the top ...
Business Wire

Amide Technologies Announces Complex Peptide Manufacturing Platform, Raises $16.5M to Expedite Frontier Drug Discovery

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Amide Technologies, a biotech that synthesizes challenging peptides, announced today that it has begun commercializing its novel peptide manufacturing platform. The ...
C&EN

Hook-and-slide strategy extends amides

Extending or trimming the length of a drug molecule’s carbon backbone by just a couple of atoms can significantly alter its activity, even if nothing else in the structure changes. So reactions that ...
Nature

Fluorinated compounds present opportunities for drug discovery

A practical method has been devised to synthesize compounds that have previously been almost impossible to make. The combination of fluorine atoms and amide groups in the compounds might be useful in ...