Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic ...

Replication origins in eukaryotic cells initiate a single round of DNA synthesis in each cell cycle. This requires the regulated binding of several conserved initiation proteins, including CDC6/Cdc18p ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

DNA, which has a double-helix structure, can have many genetic mutations and variations. Credit: NIH When cells in the human body divide, they must first make accurate copies of their DNA. The DNA ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease and ...

Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...

Researchers have demonstrated how bacteria coordinate cell division with the replication of their genetic material. In an interdisciplinary study they explain why the current concept of the bacterial ...