We have shown previously that inositol-1,4,5-trisphosphate (IP3) stimulates an efflux of ${}^{45}\text{Ca}^{2+}$ from fusogenic carrot protoplasts (M Rincón, WF Boss [1987] Plant Physiol 83: 395-398).

Inositol trisphosphate receptors (IP3Rs) are pivotal Ca²⁺ channels embedded in the membrane of the endoplasmic reticulum. Their activation by inositol 1,4,5-trisphosphate (IP3) and Ca²⁺ gives rise to ...

In this common pathway, activated phospholipase C-β hydrolyzes the inositide PI 4,5-bisphosphate to release diacylglyerol and inositol 1,4,5 trisphosphate. IP3 opens specific Ca 2+ channels releasing ...

Culminating a nearly 10 year effort, researchers have determined the atomic resolution structure of a key molecule that translates signals from a cell’s local environment into a language that the cell ...

Inositol, also called myo-inositol, D-chiro-inositol, or hexaphosphate (IP6), plays a critical role in the body’s cellular growth. Though it used to be referred to as Vitamin B8, inositol is not ...

Advanced Tools to Investigate All Compound Classes of GPCR Activation Among targets of interest for the pharmaceutical industry, GPCRs account for more than 30% of all drug screenings. The complexity ...

Inositol is a carbohydrate found in the body and in food. Though research is limited, inositol supplements may help support the treatment of certain conditions, including some metabolic and mental ...

Although it’s often referred to as vitamin B8, inositol is not a vitamin but rather a type of sugar with several important functions. It influences the action of insulin and may aid mental health and ...