Isothermal Titration Calorimetry (ITC) remains the definitive technique for quantitatively assessing the thermodynamics of molecular interactions. By directly measuring heat changes during titrations, ...
All biochemical reactions involve recognition, binding, and the formation of noncovalent complexes. Many small molecule drugs act by selectively binding to protein or nucleic acid targets and altering ...
MicroCal has introduced the new iTC200 Isothermal Titration Calorimeter using which researchers can achieve gold standard binding affinities with only 200 µl of sample. The iTC200 determines all ...
Measuring Enzyme Kinetic Parameters with the ITC Universal Enzyme Assay Method Enzymes are important in drug discovery and development since they constitute approximately one-half of all known drug ...
Isothermal titration calorimetry (ITC) is one of the most robust and convenient techniques to thermodynamically examine intermolecular interactions by detecting any reaction heat that takes place in ...
The goal of this study is to use the model system described earlier to make direct measurements of the enthalpy of helix formation at different temperatures. For this we studied model alanine peptides ...
Understanding how molecules interact is integral to numerous life science fields, such as drug discovery and development efforts. Therefore, it is essential that researchers choose the technique best ...
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