Manual patch clamping requires considerable skill and experience due to the technically challenging setup requirements, and as such, only allows recording of a small sample of cells (approximately ...

The study of electrophysiology began in the 18 th century with Luigi Aloisio Galvani’s pioneering experimental discovery. The legs of a dead frog could be induced to twitch when a small electric shock ...

Originally developed to record currents of ions flowing through channel proteins in the membranes of cells, the patch-clamp technique has become a true stalwart of the neuroscience toolbox. The paper: ...

When a sound stops, our auditory system generates a precise "offset" response that marks this moment. This enables the brain to measure the duration of a sound and detect brief gaps in communication ...