The overall duration of a receptor–ligand complex will be influenced by both the rate of ligand association (k on) and the rate of binary complex dissociation (k off) 5, as discussed below. However, ...

The therapeutic action of drugs is predicated on their physical engagement with cellular targets. Here we describe a broadly applicable method using bioluminescence resonance energy transfer (BRET) to ...

When a drug molecule binds to its target protein, it stays bound for some time before eventually unbinding the target. The actual time how long a drug molecule resides bound to its target varies among ...

A new study helps to explain what defines how long a drug molecule stays bound to its target. A new study from the University of Eastern Finland and the University of Tübingen helps to explain what ...