Because SCD can impair blood and oxygen delivery to any part of the body, it can cause a wide range of complications, including anemia, blood clots, and stroke. It can also damage organs, such as the ...

Sickle cell anemia (SCA) causes red blood cells to become stiff and C-shaped, and they can stick together. This reduces oxygen delivery and disrupts blood flow. Common symptoms include fatigue, ...

Sickle cell disease (SCD) is a group of genetic blood disorders. A person inherits SCD from their parents when they inherit two copies of the sickle cell gene, one from each parent. This hereditary ...

Sickle cell thalassemia occurs when you inherit both a sickle cell gene mutation and a thalassemia gene mutation. Symptoms are similar to other types of sickle cell disease but can vary depending on ...

Gene and cell therapies bring fresh hope to people with genetic disorders, but recovery can be complex and long-term support remains sparse. For most of her life, Genesis Jones’s daily routine ...

UCSF Benioff Children’s Hospital Oakland is enrolling patients in an innovative clinical trial that seeks to cure sickle cell disease. The trial is the first in the U.S. to apply non-viral CRISPR-Cas9 ...

Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis by means of ex vivo clustered regularly interspaced short palindromic repeats ...

How is it that you’re alive? It’s a question that we rarely ask ourselves—but it’s one that has a definite answer. We all know our heart pumps life-giving oxygen throughout our bodies. How does that ...