A new discovery may explain why so many people abandon cholesterol-lowering statins because of muscle pain and weakness.

Large-conductance calcium-activated potassium (BK) channels are critical determinants of smooth muscle function by mediating rapid feedback between intracellular calcium levels and membrane potential.

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

University of Virginia School of Medicine researchers have discovered an unknown way obesity causes high blood pressure ...

University of Virginia School of Medicine researchers have discovered an unknown way obesity causes high blood pressure – and it comes from ...