Hyperkalemic periodic paralysis (hyperPP), paramyotonia congenita (PC) and PC with myotonia permanens are closely related muscle disorders of genetic origin due to allelic mutations in the muscle ...

Sodium channels are implicated in many serious conditions such as heart disease, epilepsy and pain, making them an important potential target for drug therapies. Unfortunately, there is still much ...

The results of a new study using mice and heart muscle cells from rabbits have provided a potential molecular explanation for the abnormally rapid heartbeats known as ventricular tachyarrhythmias (VTs ...

But now, by combining structural studies and computer simulations of a bacterium-based tetrameric sodium channel and mutated variants, Takashi Sumikama from Kanazawa University, Katsumasa Irie from ...