New research published in the journal Cell Reports sheds light on the role of the TP53 gene in preventing the spread of cancer. The TP53 gene codes tumor protein p53, a tumor suppressor that stops ...

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein regulates cell division by keeping cells from growing and dividing too fast or in an ...

Men who have mutations in a gene called TP53 have a high risk of developing aggressive prostate cancer, a multicenter research team in the United States has found. The findings were reported in the ...

p53 mutants are among the most common protein variants expressed in cancer cells. Classifying TP53 status in human cancer as ‘inactivated’ or ‘loss-of-function’ is misleading. Many mutant p53 variants ...

One sperm donor was linked to nearly 200 births across multiple countries Several children inherited a high-risk TP53 cancer mutation Case exposes gaps in genetic screening and donor regulation Go to ...

Higgins is an advocate for people with Li-Fraumeni syndrome. I was born with an inherited cancer syndrome, Li-Fraumeni syndrome (LFS). A mutation on my Tp53 cancer suppressor gene makes me susceptible ...

Drugging the Master Regulator TP53 in Cancer: Mission Possible? The following represents disclosure information provided by the author of this manuscript. All relationships are considered compensated ...

Inhibiting the immune receptor protein TLR4 may not be a wise treatment strategy in all cancers, researchers have discovered, countering previously held beliefs, Countering previously held beliefs, ...

Luveltamab tazevibulin, a novel ADC, showed encouraging responses in platinum-resistant ovarian cancer, with a 32% ORR and a ...