The Annals of Applied Statistics, Vol. 11, No. 4 (December 2017), pp. 2027-2051 (25 pages) Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, ...
The design problem for the estimation of variance components by the method of unweighted squares of means, under a multifactor random effects model, is considered. First it is shown that with the ...
We first describe the likelihood of the commonly used variance components model, for example as in Amos. 5 Since the total likelihood is a product of likelihood over all the families under study, we ...
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