Focal adhesions are known as signalling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signalling cascades. However, ...

Immunofluorescence image showing S100A11 (green) localization to focal adhesions and actin stress fibers in a HeLa cell. Microtubules are labeled in red. Researchers at Kanazawa University report in ...

Focal adhesions are known as signaling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signaling cascades. However, ...

Explore new findings on ovarian cancer and how blocking focal adhesion kinase can enhance immune response in treatment.

The following represents disclosure information provided by the author of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted ...

“Cell migration is required and essential for metazoan development, tissue regeneration and repair, as well as in immune surveillance. Many diseases such as cancer, fibrosis, and inherited ...

“Focus has been on how cells become mechanosensitive, how cell adhesion became mechanosensitive through the recruitment of mechanosensitive proteins like talin, vinculin, and also other proteins,” ...

Overexpression of focal adhesion kinase (FAK) is linked to worse prognosis and greater risk of metastasis in colorectal, cervical, breast and skin cancers. Despite its attractiveness as a therapeutic ...