Nature

Transient expression of the Bcl-2 family member, A1-a, results in nuclear localization and resistance to staurosporine-induced apoptosis

A1-a is a Bcl-2 family member found primarily in hematopoietic cells. 9 Initial studies have shown that A1-a can protect cells from undergoing apoptosis in a manner similar to Bcl-2. 34 When 32Dcl3 ...
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Small molecule pan-bcl-2 inhibitor AT-101 induces apoptosis in NSCLC by up-regulating noxa and enhances antitumor activity of docetaxel or targeted kinase inhibitors

Single nucleotide polymorphisms of TSER, ATM, RecQ1 genes association with survival in pancrease cancer This is an ASCO Meeting Abstract from the 2009 ASCO Annual Meeting I. This abstract does not ...
ascopubs.org

Paclitaxel in combination with AT-101 induces apoptosis via supressing Bcl-2, bcl-XL, mcl-1 proteins in human breast cancer cells.

Effect of dormant cancer cells on angiogenesis after resisting chemotherapy. Multicentric survey on dose reduction in cancer drug therapy: Detection and measurement of critical phenomena as potential ...
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Researchers advance strategies to clear chemotherapy's 'zombie' cells

Scientists are developing therapies to eliminate chemotherapy-induced senescent 'zombie' cells, which may fuel inflammation and cancer relapse. These approaches include repurposing existing cancer ...