Figure 3: The Apc1 auto-inhibitory segment binds to the C-box binding site and mimics the Cdc20 C box. Figure 4: Mechanism for APC/C activation by mitotic phosphorylation and the molecular basis for ...
The APC (also called the APC/C) is a multisubunit ubiquitin ligase that initiates anaphase and mitotic exit by ubiquitinating substrates, including cyclin B1 and securin, to target them for ...
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