New research published in the journal Cell Reports sheds light on the role of the TP53 gene in preventing the spread of cancer. The TP53 gene codes tumor protein p53, a tumor suppressor that stops ...

In Brazil, the early detection of genetic alterations in lung cancer through liquid biopsies could be a valuable tool for ...

p53 mutants are among the most common protein variants expressed in cancer cells. Classifying TP53 status in human cancer as ‘inactivated’ or ‘loss-of-function’ is misleading. Many mutant p53 variants ...

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein regulates cell division by keeping cells from growing and dividing too fast or in an ...

Men who have mutations in a gene called TP53 have a high risk of developing aggressive prostate cancer, a multicenter research team in the United States has found. The findings were reported in the ...

PRESS RELEASEAB SCIENCE REPORTS FOURTH CONSECUTIVE CASE OF RESPONSE FROM PHASE 1 DATA FOR THE COMBINATION OF AB8939 WITH VENETOCLAX FOR THE ...

One sperm donor was linked to nearly 200 births across multiple countries Several children inherited a high-risk TP53 cancer mutation Case exposes gaps in genetic screening and donor regulation Go to ...

Although the link between mutant TP53 and human cancer is unequivocal, a significant knowledge gap exists in clinically actionable molecular targets in Li-Fraumeni syndrome (LFS), a highly penetrant ...

Inhibiting the immune receptor protein TLR4 may not be a wise treatment strategy in all cancers, researchers have discovered, countering previously held beliefs, Countering previously held beliefs, ...