This graphical representation shows the hypothesis about how the novel concept of trained innate immunity can contribute to the pathogenesis of bronchiectasis through epigenetic reprogramming …

Jul 4, 2024 · Although bronchiectasis research has significantly increased over the past years and different endotypes have been identified, there are still major gaps in the understanding of the …

Aug 27, 2025 · Bronchiectasis is an uncommon disease, most often secondary to an infectious process, that results in the abnormal and permanent distortion of one or more of the conducting bronchi or …

There are multiple underlying causes including severe infections, mycobacterial disease, auto-immune conditions, hypersensitivity disorders, and genetic conditions. The patho-physiology of disease is …

Bronchiectasis is a condition with heterogeneous inciting factors that result in impaired ability to clear bacteria from the airways, perpetuating ongoing inflammation, and resulting progressive dam-age to …

Bronchiectasis refers to dilation, thickening, and destruction of larger bronchi caused by chronic infection and inflammation. Common causes are cystic fibrosis, immune defects, and recurrent infections, …

Aug 1, 2025 · Bronchiectasis is associated with multiple medical conditions, including infectious, immune-related, and congenital causes [8]. Inflammation is central to the pathogenesis and …

Micro-organisms trigger the release of toxins and an inflammatory response within the airways. This inflammatory response includes the release of neutrophils, lymphocytes and macrophages within the …

Loss of diversity of the normal lung microbiota and dominance of proteobacteria such as Pseudomonas and Haemophilus are features of severe bronchiectasis and link to poor outcomes. Ciliary …

Jun 1, 2011 · Bronchiectasis arises from chronic airway inflammation that is driven by persistent infection. The main clinical manifestation is a productive cough. The pathogenesis of this condition is …