Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1][2] They also respond to instances of …

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreased oxygen level in the cellular environment. Various isoforms and splice variants have been identified and their …

May 4, 2025 · The current review highlights the different roles and regulatory mechanisms of HIF-1α and HIF-2α isoforms, focusing on their involvement in cell metabolism and the multi-step …

Mar 16, 2025 · We propose an alternative model focused on understanding the dynamics of HIFs’ activity within its physiological context. Our model suggests that HIFs would not respond to but …

Hypoxia-inducible factor (HIF) is defined as a key transcription factor that mediates physiological responses to low oxygen levels by regulating the expression of genes involved in processes …

Hypoxia-inducible factor (HIF) is a transcription factor composed of two subunits, an oxygen regulated α subunit (HIF-α) and a constitutively expressed β subunit (HIF-β), which responds …

HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, …

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreased oxygen level in the cellular environment. Various isoforms and splice variants have been identified and their …

May 4, 2025 · The current review highlights the different roles and regulatory mechanisms of HIF-1α and HIF-2α isoforms, focusing on their involvement in cell metabolism and the multi-step …

Jan 18, 2025 · In this review, we describe an overview of the structure, expression, and DNA binding of the HIF-1 and HIF-2 complexes. We use the terminology ‘canonical’ to describe …